Moroz Leonid L.

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Leonid L.

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  • Article
    Cephalopod genomics : a plan of strategies and organization
    (Genomic Standards Consortium, 2012-09-26) Albertin, Caroline B. ; Bonnaud, Laure ; Brown, C. Titus ; Crookes-Goodson, Wendy J. ; da Fonseca, Rute R. ; Di Cristo, Carlo ; Dilkes, Brian P. ; Edsinger-Gonzales, Eric ; Freeman, Robert J. ; Hanlon, Roger T. ; Koenig, Kristen M. ; Lindgren, Annie R. ; Martindale, Mark Q. ; Minx, Patrick ; Moroz, Leonid L. ; Nodl, Marie-Therese ; Nyholm, Spencer V. ; Ogura, Atsushi ; Pungor, Judit R. ; Rosenthal, Joshua J. C. ; Schwarz, Erich M. ; Shigeno, Shuichi ; Strugnell, Jan M. ; Wollesen, Tim ; Zhang, Guojie ; Ragsdale, Clifton W.
    The Cephalopod Sequencing Consortium (CephSeq Consortium) was established at a NESCent Catalysis Group Meeting, “Paths to Cephalopod Genomics- Strategies, Choices, Organization,” held in Durham, North Carolina, USA on May 24-27, 2012. Twenty-eight participants representing nine countries (Austria, Australia, China, Denmark, France, Italy, Japan, Spain and the USA) met to address the pressing need for genome sequencing of cephalopod molluscs. This group, drawn from cephalopod biologists, neuroscientists, developmental and evolutionary biologists, materials scientists, bioinformaticians and researchers active in sequencing, assembling and annotating genomes, agreed on a set of cephalopod species of particular importance for initial sequencing and developed strategies and an organization (CephSeq Consortium) to promote this sequencing. The conclusions and recommendations of this meeting are described in this White Paper.
  • Preprint
    Schistosoma mansoni : use of a fluorescent indicator to detect nitric oxide and related species in living parasites
    ( 2005-12-20) Kohn, Andrea B. ; Lea, Jeanne M. ; Moroz, Leonid L. ; Greenberg, Robert M.
    Nitric oxide (NO) is synthesized enzymatically by nitric oxide synthase (NOS). Several groups have previously presented evidence for NOS activity and immunoreactivity in several parasitic platyhelminths, including schistosomes. Here, we use 4,5-diaminofluorescein-2 diacetate (DAF-2 DA), a fluorescent indicator of NO, to detect NO in living schistosomes. In adult worms, DAF-2 fluorescence is found selectively in epithelial-like cells. Fluorescence increases when worms are incubated in L-arginine, the precursor of NO synthesis, and decreases dramatically in the presence of the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), indicating that predicted NO release may be NOS-dependent, and that enzymatic NO signaling pathways may play an important role in schistosome physiology.