Martindale Mark Q.

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Martindale
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Mark Q.
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  • Article
    Cephalopod genomics : a plan of strategies and organization
    (Genomic Standards Consortium, 2012-09-26) Albertin, Caroline B. ; Bonnaud, Laure ; Brown, C. Titus ; Crookes-Goodson, Wendy J. ; da Fonseca, Rute R. ; Di Cristo, Carlo ; Dilkes, Brian P. ; Edsinger-Gonzales, Eric ; Freeman, Robert J. ; Hanlon, Roger T. ; Koenig, Kristen M. ; Lindgren, Annie R. ; Martindale, Mark Q. ; Minx, Patrick ; Moroz, Leonid L. ; Nodl, Marie-Therese ; Nyholm, Spencer V. ; Ogura, Atsushi ; Pungor, Judit R. ; Rosenthal, Joshua J. C. ; Schwarz, Erich M. ; Shigeno, Shuichi ; Strugnell, Jan M. ; Wollesen, Tim ; Zhang, Guojie ; Ragsdale, Clifton W.
    The Cephalopod Sequencing Consortium (CephSeq Consortium) was established at a NESCent Catalysis Group Meeting, “Paths to Cephalopod Genomics- Strategies, Choices, Organization,” held in Durham, North Carolina, USA on May 24-27, 2012. Twenty-eight participants representing nine countries (Austria, Australia, China, Denmark, France, Italy, Japan, Spain and the USA) met to address the pressing need for genome sequencing of cephalopod molluscs. This group, drawn from cephalopod biologists, neuroscientists, developmental and evolutionary biologists, materials scientists, bioinformaticians and researchers active in sequencing, assembling and annotating genomes, agreed on a set of cephalopod species of particular importance for initial sequencing and developed strategies and an organization (CephSeq Consortium) to promote this sequencing. The conclusions and recommendations of this meeting are described in this White Paper.
  • Preprint
    Current directions and future perspectives from the third Nematostella research conference
    ( 2014-06) Tarrant, Ann M. ; Gilmore, Thomas D. ; Reitzel, Adam M. ; Levy, Oren ; Technau, Ulrich ; Martindale, Mark Q.
    The third Nematostella vectensis Research Conference took place in December 2013 in Eilat, Israel, as a satellite to the 8th International Conference on Coelenterate Biology. The starlet sea anemone, Nematostella vectensis, has emerged as a powerful cnidarian model, in large part due to the extensive genomic and transcriptomic resources and molecular approaches that are becoming available for Nematostella, which were the focus of several presentations. In addition, research was presented highlighting the broader utility of this species for studies of development, circadian rhythms, signal transduction, and gene–environment interactions.
  • Article
    Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis
    (Oxford University Press, 2019-03-25) Xu, Xiaocui ; Li, Guoqiang ; Li, Congru ; Zhang, Jing ; Wang, Qiang ; Simmons, David K. ; Chen, Xuepeng ; Wijesena, Naveen ; Zhu, Wei ; Wang, Zhanyang ; Wang, Zhenhua ; Ju, Bao ; Ci, Weimin ; Lu, Xuemei ; Yu, Daqi ; Wang, Qian-fei ; Aluru, Neelakanteswar ; Oliveri, Paola ; Zhang, Yong E. ; Martindale, Mark Q. ; Liu, Jiang
    Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular innovations. To search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans. We focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and mammals. Here, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in vertebrates. Functional association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for invertebrates. Interestingly, the single HOX cluster of invertebrates maintains unmethylated status in all stages examined. In contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis. Notably, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals. Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.