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  • Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase 

    Alavian, Kambiz N.; Li, Hongmei; Collis, Leon P.; Bonanni, Laura; Zeng, Lu; Sacchetti, Silvio; Lazrove, Emma; Nabili, Panah; Flaherty, Benjamin; Graham, Morven; Chen, Yingbei; Messerli, Shanta M.; Mariggio, Maria A.; Rahner, Christoph; McNay, Ewan; Shore, Gordon; Smith, Peter J. S.; Hardwick, J. Marie; Jonas, Elizabeth A. (2011-06)
    Anti-apoptotic BCL-2 family proteins such as Bcl-xL protect cells from death by sequestering apoptotic molecules, but also contribute to normal neuronal function. We find in hippocampal neurons that Bcl-xL enhances the ...