The tunicate Ciona : a model system for understanding the relationship between regeneration and aging
Jeffery, William R.
MetadataShow full item record
The use of the tunicate Ciona intestinalis as a model system to study the relationship between regeneration and aging is reviewed. Ciona has powerful regeneration capacities, which fade with age. Some additional benefits are a relatively short life span, the ability to study regeneration in vitro, the close phylogenetic relationship between tunicates and vertebrates, and the host of molecular tools already established in this system. The neural complex (NC), the oral siphon (OS), and the oral siphon pigment organs (OPO) have high capacities for regeneration. However, these organs show an inverse relationship between rate of regeneration and age. The ability to regenerate a complete OS disappears in the oldest animals of a natural population, probably due to the inability to form a blastema at the wound site. Effects on blastema formation could also be involved in the reduction of NC regeneration capacity. The fidelity of OPO restoration is also compromised by excess differentiation of precursor cells in local siphon niches in the oldest animals. The Ciona model provides a pathway to understand the molecular basis of these phenomena.
© 2014 The Author(s). This is an Open Access article. The definitive version was published in Invertebrate Reproduction & Development 59, Supple. 1 (2015): 17-22, doi:10.1080/07924259.2014.925515.
Showing items related by title, author, creator and subject.
Closing the wounds : one hundred and twenty five years of regenerative biology in the ascidian Ciona intestinalis Jeffery, William R. (2014-06)This year marks the 125th anniversary of the beginning of regeneration research in the ascidian Ciona intestinalis. A brief note was published in 1891 reporting the regeneration of the Ciona neural complex and siphons. ...
Jeffery, William R. (2015-04)Regeneration studies in the tunicate Ciona intestinalis have recently been focused on the potential of adult stem cells to replace injured tissues and organs during the adult life cycle using the oral siphon (OS) as a ...
Auger, Helene; Sasakura, Yasunori; Joly, Jean-Stephane; Jeffery, William R. (2009-12-06)Ascidians have powerful capacities for regeneration but the underlying mechanisms are poorly understood. Here we examine oral siphon regeneration in the solitary ascidian Ciona intestinalis. Following amputation, the ...