A novel-type luciferin from Siberian luminous earthworm Fridericia heliota : structure elucidation by spectral studies and total synthesis
Petushkov, Valentin N.
Dubinnyi, Maxim A.
Tsarkova, Aleksandra S.
Rodionova, Natalja S.
Baranov, Mikhail S.
Kublitski, Vadim S.
Yampolsky, Ilia V.
MetadataShow full item record
We report structure elucidation and synthesis of the luciferin from the recently discovered luminous earthworm Fridericia heliota. This luciferin represents a key component of a novel ATP-dependent bioluminescence system. The UV, fluorescence, NMR and HRMS spectral studies were performed on 5 mkg of the isolated substance, and gave four isomeric structures, conforming with spectral data. These isomers were chemically synthesized and one of them was found to produce light in the reaction with a protein extract from Fridericia. The novel luciferin was found to have an unusual deeply modified peptidic nature, implying an unprecedented mechanism of action.
Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Wiley-VCH Verlag GmbH & Co for personal use, not for redistribution. The definitive version was published in Angewandte Chemie International Edition 53 (2014): 5566–5568, doi:10.1002/anie.201400529.
Showing items related by title, author, creator and subject.
Mass-induced sea level change in the northwestern North Pacific and its contribution to total sea level change Cheng, Xuhua; Li, Lijuan; Du, Yan; Wang, Jing; Huang, Rui Xin (John Wiley & Sons, 2013-08-02)Over the period 2003–2011, the Gravity Recovery and Climate Experiment (GRACE) satellite pair revealed a remarkable variability in mass-induced sea surface height (MSSH) in the northwestern North Pacific. A significant ...
Auxiliary material for "Estimates of new and total productivity in central Long Island Sound from in situ measurements of nitrate and dissolved oxygen" Collins, James R.; Raymond, Peter A.; Bohlen, Walter Franklin; Howard-Strobe, Mary M. (2013)Biogeochemical cycles in estuaries are regulated by a diverse set of physical and biological variables that operate over a variety of time scales. Using in situ optical sensors, we conducted a high-frequency time-series ...
Unexpected diversity of bacteria capable of carbon monoxide oxidation in a coastal marine environment, and contribution of the Roseobacter-cssociated clade to total CO oxidation Tolli, John D.; Sievert, Stefan M.; Taylor, Craig D. (American Society for Microbiology, 2006-03)The species diversity, phylogenetic affiliations, and physiological activity rates of carbon monoxide-oxidizing microorganisms were investigated, using new isolates from surface waters collected from the coast of New England ...