Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites
MetadataShow full item record
Synaptically activated changes in dendritic [Ca2+]i affect many important physiological processes including synaptic plasticity and gene expression. The location, magnitude, and time course of these changes can determine which mechanisms are affected. Therefore, it is important to understand the processes that control and modulate these changes. One important source is Ca2+ entering through voltage gated Ca2+ channels opened by action potentials backpropagating over the dendrites (bAPs). Here we examine how [Ca2+]i changes, caused by regenerative Ca2+ release from internal stores (Ca2+ waves) or by regenerative Ca2+ entry through NMDA receptors (NMDA spikes) affect subsequent bAP evoked [Ca2+]i changes. These large [Ca2+]i increases suppressed the bAP signals in the regions where the preceding [Ca2+]i increases were largest. The suppression was proportional to the magnitude of the large [Ca2+]i change and was insensitive to kinase and phosphatase inhibitors, consistent with suppression due to Ca2+ dependent inhibition of Ca2+ channels.
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of The Physiological Society for personal use, not for redistribution. The definitive version was published in Journal of Physiology 589 (2011): 4903-4920, doi:10.1113/jphysiol.2011.216564.
Showing items related by title, author, creator and subject.
Developmental profile of localized spontaneous Ca2+ release events in the dendrites of rat hippocampal pyramidal neurons Miyazaki, Kenichi; Manita, Satoshi; Ross, William N. (2012-08)Recent experiments demonstrate that localized spontaneous Ca2+ release events can be detected in the dendrites of pyramidal cells in the hippocampus and other neurons (J. Neurosci. 29:7833-7845, 2009). These events have ...
Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons Chen, Xixi; Johnston, Daniel (Society for Neuroscience, 2005-04-13)A diversity of ion channels contributes to the active properties of neuronal dendrites. From the apical dendrites of hippocampal CA1 pyramidal neurons, we recorded inwardly rectifying K+ channels with a single-channel ...
Ca2+ sparks and puffs are generated and interact in rat hippocampal CA1 pyramidal neuron dendrites Miyazaki, Kenichi; Ross, William N. (Society for Neuroscience, 2013-11-06)1,4,5-Inositol trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) mediate release of Ca2+ from internal stores in many neurons. The details of the spatial and temporal characteristics of these signals and their ...