Epigenetic regulation during mammalian oogenesis
Albertini, David F.
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The advent of the epigenetic era has sparked a new frontier in molecular research and the understanding of how development can be regulated beyond direct alterations of the genome. Thus far, the focal point of epigenetic regulation during development has been chromatin modifications that control differential gene expression by DNA methylation and histone alterations. But what of events that alter gene expression without direct influence on the DNA itself? This review focuses on epigenetic pathways regulating development from oogenesis to organogenesis and back that do not involve methylation of cytosine in DNA. We discuss target components of epigenetic modification such as organelle development, compartmentalization of maternal factors and molecular mediators in the oocyte and how these factors acting during oogenesis impact on later development. Epigenetic regulation of development, be it via cytosine methylation or not, has wide ranging effects on the subsequent success of a pregnancy and the intrinsic health of offspring. Perturbations in epigenetic regulation have been clearly associated with disease states in adult offspring including type II diabetes, hypertension, cancers and infertility. A clear understanding of all epigenetic mechanisms is paramount when considering the increased utilization of assisted reproductive techniques and the risks associated with their use.
Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here by permission of CSIRO Publishing for personal use, not for redistribution. The definitive version was published in Reproduction, Fertility and Development 20 (2007): 74-80, doi:10.1071/RD07181.