Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
Ferguson, D. J. P.
Hajduk, Stephen L.
Day, K. P.
MetadataShow full item record
Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
Author Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025.
Showing items related by title, author, creator and subject.
Density currents in the Chicago River : characterization, effects on water quality, and potential sources Jackson, P. Ryan; Garcia, Carlos M.; Oberg, Kevin A.; Johnson, Kevin K.; Garcia, Marcelo H. (2008-03)Bidirectional flows in a river system can occur under stratified flow conditions and in addition to creating significant errors in discharge estimates, the upstream propagating currents are capable of transporting contaminants ...
Evaluation of an acoustic remote sensing method for frontal-zone studies using double-diffusive instability microstructure data and density interface data from intrusions Duda, Timothy F.; Lavery, Andone C.; Sellers, Cynthia J. (Elsevier, 2016-10-19)Understanding intrusive exchange at oceanic water mass fronts may depend on building data-constrained models of the processes, but obtaining the needed representative and comprehensive data is challenging. Acoustic imaging ...
Distribution of postsynaptic density (PSD)-95 and Ca2+/calmodulin-dependent protein kinase II at the PSD Petersen, Jennifer D.; Chen, Xiaobing; Vinade, Lucia; Dosemeci, Ayse; Lisman, John E.; Reese, Thomas S. (Society for Neuroscience, 2003-12-03)Postsynaptic densities (PSDs) contain proteins that regulate synaptic transmission. We determined the positions of calcium/calmodulin-dependent protein kinase II (CaMKII) and PSD-95 within the three-dimensional structure ...