Scores of distinguished biologists from around the world come to the MBL to collaborate and conduct research. They use marine and other organisms as model systems for their research.

These researchers participate in a number of established MBL groups including but not limited to:

  • MBL Summer Research Fellows
  • Dart Scholars
  • Grass Faculty Awardees
  • NeuroImaging Cluster
  • Grass Fellows

Recent Submissions

  • Visualizing calcium flux in freely moving nematode embryos 

    Ardiel, Evan L.; Kumar, Abhishek; Marbach, Joseph; Christensen, Ryan; Gupta, Rishi; Duncan, William; Daniels, Jonathan S.; Stuurman, Nico; Colón-Ramos, Daniel; Shroff, Hari (2017-02)
    The lack of physiological recordings from Caenorhabditis elegans embryos stands in stark contrast to the comprehensive anatomical and gene expression datasets already available. Using light-sheet fluorescence microscopy ...
  • Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases 

    Brady, Scott T.; Morfini, Gerardo A. (2017-04)
    Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases (AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by early deficits in synaptic function ...
  • The origin of vertebrate gills 

    Gillis, J. Andrew; Tidswell, Olivia R. A. (Elsevier, 2017-02-09)
    Pharyngeal gills are a fundamental feature of the vertebrate body plan. However, the evolutionary history of vertebrate gills has been the subject of a long-standing controversy. It is thought that gills evolved independently ...
  • HIV glycoprotein Gp120 impairs fast axonal transport by activating Tak1 signaling pathways 

    Berth, Sarah; Mesnard-Hoaglin, Nichole; Wang, Bin; Kim, Hajwa; Song, Yuyu; Sapar, Maria; Morfini, Gerardo A.; Brady, Scott T. (Sage, 2016-11-01)
    Sensory neuropathies are the most common neurological complication of HIV. Of these, distal sensory polyneuropathy (DSP) is directly caused by HIV infection and characterized by length-dependent axonal degeneration of ...
  • Introducing the microbiome into Precision Medicine 

    Kuntz, Thomas M.; Gilbert, Jack A. (2016-11)
    Understanding how individual people respond to medical therapy is a key facet of improving the odds ratio that interventions will have a positive impact. Reducing the non-responder rate for an intervention or reducing ...
  • Disturbance regimes predictably alter diversity in an ecologically complex bacterial system 

    Gibbons, Sean M.; Scholz, Monika; Hutchison, Alan L.; Dinner, Aaron R.; Gilbert, Jack A.; Coleman, Maureen L. (American Society for Microbiology, 2016-12-20)
    Diversity is often associated with the functional stability of ecological communities from microbes to macroorganisms. Understanding how diversity responds to environmental perturbations and the consequences of this ...
  • Physical basis of large microtubule aster growth 

    Ishihara, Keisuke; Korolev, Kirill S.; Mitchison, Timothy J. (eLife, 2016-11-28)
    Microtubule asters - radial arrays of microtubules organized by centrosomes - play a fundamental role in the spatial coordination of animal cells. The standard model of aster growth assumes a fixed number of microtubules ...
  • How do we make indoor environments and healthcare settings healthier? 

    Gilbert, Jack A. (John Wiley & Sons, 2016-10-17)
    It is now well accepted that our modern lifestyle has certain implications for our health (Schaub et al., 2006), mainly as a result of our willingness to remove ourselves from the biological diversity of our natural ...
  • Shortening of microtubule overlap regions defines membrane delivery sites during plant cytokinesis 

    de Keijzer, Jeroen; Kieft, Henk; Ketelaar, Tijs; Goshima, Gohta; Janson, Marcel E. (2016-12)
    Different from animal cells that divide by constriction of the cortex inwards, cells of land plants divide by initiating a new cell wall segment from their centre. For this, a disk-shaped, membrane-enclosed precursor ...
  • Is axonal degeneration a key early event in Parkinson’s disease? 

    Kurowska, Zuzanna; Kordower, Jeffrey H.; Stoessl, A Jon; Burke, Robert E.; Brundin, Patrik; Yue, Zhenyu; Brady, Scott T.; Milbrandt, Jeffrey; Trapp, Bruce D.; Sherer, Todd B.; Medicetty, Satish (2016-06)
    Recent research suggests that in Parkinson’s disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled ‘Axonal Pathology in Parkinson’s ...
  • Tracking recurrence of correlation structure in neuronal recordings 

    Neymotin, Samuel A.; Talbot, Zoe N.; Jung, Jeeyune Q.; Fenton, André A.; Lytton, William W. (Elsevier, 2016-10-13)
    Correlated neuronal activity in the brain is hypothesized to contribute to information representation, and is important for gauging brain dynamics in health and disease. Due to high dimensional neural datasets, it is ...
  • Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation 

    Jeyifous, Okunola; Lin, Eric I.; Chen, Xiaobing; Antinone, Sarah E.; Mastro, Ryan; Drisdel, Renaldo; Reese, Thomas S.; Green, William N. (2016-08)
    PSD95 and SAP97 are homologous scaffold proteins with different N-terminal domains, possessing either a palmitoylation site (PSD95) or an L27 domain (SAP97). Here, we measured PSD95 and SAP97 conformation in vitro and ...
  • Prey capture by the cosmopolitan hydromedusae, Obelia spp., in the viscous regime 

    Sutherland, Kelly R.; Gemmell, Brad J.; Colin, Sean P.; Costello, John H. (John Wiley & Sons, 2016-08-29)
    Obelia spp. are cnidarian hydromedusae with a cosmopolitan distribution but very little is known about their feeding. The small size of Obelia (bell diameter ∼ 1 mm, tentacle width ∼ 0.05 mm) suggests that feeding occurs ...
  • Transitions in morphologies, fluid regimes, and feeding mechanisms during development of the medusa Lychnorhiza lucerna 

    Nagata, Renato M.; Morandini, André C.; Colin, Sean P.; Migotto, Alvaro E.; Costello, John H. (2016-08)
    The early ontogeny of scyphomedusae involves morphological and functional transitions in body plans that affect the predators’ propulsive and feeding strategies. We applied high-speed videography, digital particle image ...
  • An efficient system for selectively altering genetic information within mRNAs 

    Montiel-González, Maria Fernanda; Vallecillo-Viejo, Isabel C.; Rosenthal, Joshua J. C. (Oxford University Press, 2016-08-23)
    Site-directed RNA editing (SDRE) is a strategy to precisely alter genetic information within mRNAs. By linking the catalytic domain of the RNA editing enzyme ADAR to an antisense guide RNA, specific adenosines can be ...
  • Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition 

    Cox, Kristine; Combs, Benjamin; Abdelmesih, Brenda; Morfini, Gerardo A.; Brady, Scott T.; Kanaan, Nicholas M. (Elsevier, 2016-07-29)
    Misfolded tau proteins are characteristic of tauopathies, but the isoform composition of tau inclusions varies by tauopathy. Using aggregates of the longest tau isoform (containing 4 microtubule-binding repeats and 4-repeat ...
  • Five factors can reconstitute all three phases of microtubule polymerization dynamics 

    Moriwaki, Takashi; Goshima, Gohta (Rockefeller University Press, 2016-10-31)
    Cytoplasmic microtubules (MTs) undergo growth, shrinkage, and pausing. However, how MT polymerization cycles are produced and spatiotemporally regulated at a molecular level is unclear, as the entire cycle has not been ...
  • Transcriptome of the Caribbean stony coral Porites astreoides from three developmental stages 

    Mansour, Tamer A.; Rosenthal, Joshua J. C.; Brown, C. Titus; roberson, loretta (BioMed Central, 2016-08-02)
    Porites astreoides is a ubiquitous species of coral on modern Caribbean reefs that is resistant to increasing temperatures, overfishing, and other anthropogenic impacts that have threatened most other coral species. We ...
  • Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5 

    Nunez, Illyce; Rodriguez Pino, Marbelys; Wiley, David J.; Das, Maitreyi E.; Chen, Chuan; Goshima, Tetsuya; Kume, Kazunori; Hirata, Dai; Toda, Takashi; Verde, Fulvia (eLife, 2016-07-30)
    RNA-binding proteins contribute to the formation of ribonucleoprotein (RNP) granules by phase transition, but regulatory mechanisms are not fully understood. Conserved fission yeast NDR (Nuclear Dbf2-Related) kinase Orb6 ...
  • Perineuronal nets enhance the excitability of fast-spiking neurons 

    Balmer, Timothy (Society for Neuroscience, 2016-07-11)
    Perineuronal nets (PNNs) are specialized complexes of extracellular matrix molecules that surround the somata of fast-spiking neurons throughout the vertebrate brain. PNNs are particularly prevalent throughout the auditory ...

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